Methyl-Guard Plus

Various conditions and stressors can have an adverse impact on the body’s methylation cycle. Nutrient deficiencies, environmental exposures, and other aspects of a modern lifestyle can cause inefficient methylation. In addition, approximately 60 percent of U.S. adults have a genetic variation that makes it difficult for their methylation cycle to function optimally.

Thorne’s Methyl-Guard Plus features betaine (trimethylgycine), methylated vitamin B12 (methylcobalamin) and folate (5-MTHF), as well as the active forms of vitamins B2 and B6, for providing efficient nutritional support for the body’s methylation challenges.*

Benefits of Thorne’s Methyl-Guard Plus

• Nutritional support for individuals who have MTHFR gene mutations*
• Enhanced cellular energy production fights fatigue*
• Helps maintain a healthy homocysteine level in the blood, which supports cardiovascular, cognitive, and bone health*
• Promotes fat metabolism and lean body composition*
• Supports neurotransmitter production – natural chemicals that play an important role in nervous system functions, like attention, focus, mood, and sleep*
• Promotes liver detoxification of many substances, including hormones like estrogen*

Why is methylation important

Methylation is a simple reaction where a small molecule known as a “methyl group” is transferred from one substance to another. Methylation significantly impacts many biochemical reactions in the body and plays a beneficial role in:

• Cardiovascular health
• Cellular energy production
• Fat metabolism
• Neurological function
• DNA production
• Liver detoxification processes
• Eye health
• Histamine balance

Who can benefit from Thorne's Methyl-Guard Plus:

• Individuals with mutations to MTHFR and other genes that adversely affect methylation*
• Aging individuals wanting to support their cardiovascular, cognitive, and metabolic health*
• Women seeking support for estrogen metabolism and bone health*
• Individuals wanting nutritional support for fat metabolism and maintenance of a healthy body composition*
• Anyone with limited consumption of methylation-supportive foods like green leafy vegetables, legumes, and cruciferous vegetables

Features of Thorne's Methyl-Guard Plus

• Betaine, also known as trimethylglycine, is a superior methyl donor
• The methylated forms of vitamin B12 (methylcobalamin) and folate (5-MTHF) benefit individuals with certain gene mutations*
• Active forms of vitamins B2 and B6 – key cofactors in methylation processes
• B vitamins in their active, tissue-ready forms means your body gets the greatest benefit with the least additional work*
• Robust methylation support in fewer capsules per day than Thorne’s original Methyl-Guard®

Suggested Use / Directions

Take 1-3 capsules daily or as recommended by your health professional.

Serving Size

Three Capsules

Amount Per Serving

• Riboflavin (as Riboflavin 5’-Phosphate Sodium) ... 90 mg
• Vitamin B6 (as Pyridoxal 5’-Phosphate) ... 45 mg
• Folate (3 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) ... 5 mg DFE
• Vitamin B12 (as Methylcobalamin) ... 3 mg
• Betaine Anhydrous (Trimethylglycine) ... 1.8 g

Other Ingredients

Calcium (Citrate), Calcium Laurate, Hypromellose Capsule

ALLERGY WARNING

This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.

PREGNANCY

If pregnant, consult your health professional before using this product.

INTERACTIONS

5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, 5-MTHF has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.